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The 42nd and 43rd JUACEP Seminars

June 29, 2017

Prof. Katsuo Kurabayashi of Univ. Michigan talked about why do research (the 42nd Seminar) for Japanese students and about his study field titled "Electrokinetic and nanomechanical transport of biomolecules for ultrasensitive bio-detection" (the 43rd Seminar) for JUACEP students.


(The 42nd)

(The 43rd)
On-chip high-throughput, ultrasensitive screening for emerging diagnostic applications and innovative scientific discovery require systems for detecting protein concentrations in the nano- to picomolar range (~ a few molecules per cell). Low volume technology is expected to promise sensitivity, cost, and speed advantages associated with small scales. However, such small scales pose crucial challenges to biodetection owing to friction against fluid transport at low Reynolds numbers and random motion of molecules. These challenges significantly compromise on-chip nano-biosensors. To address these issues, we have developed integrated microsystems that control mass transport of biomolecules under micro- to nanofluidic environments with AC electroosmosis flow and adenosine triphosphate (ATP)- fueled motor proteins. Our system integrates AC electroosmosis flow-inducing microelectrodes with plasmonic nanoparticle biosensors. Another system implements nanoscale mechanical manipulation of the stochastic motion of motor proteins for protein concentration. Motor proteins are nanometer-scale biomaterials that convert chemical energy stored in ATP into mechanical work. This seminar talk discusses fundamental statistical mechanics, electrodydrodynamics, and mass transport theories, nanomaterial synthesis, and microfabrication that provide the foundations of our technological approaches and their impacts on clinical diagnosis of immune diseases.


Graduate School and School of Engineering,Nagoya University
Furo-cho, Chikusa-ku, Nagoya,
464-8603, JAPAN

mail juacep-office@engg.nagoya-u.ac.jp