The 49th JUACEP Seminar

We welcomed Prof. Katsuo Kurabayashi of University of Michigan. He delivered a talk titled "High-performance nanoplasmonic biosensors for critical medicine."

Summary:
In recent years, substantial research has focused on developing nanoplasmonic biosensors aimed at point-of-care (POC) immunological testing due to their robustness, label-free nature enabling rapid analysis, ease of integration in a miniaturized system, simple optics. However, their implementations in real clinical settings are yet to be realized due to their limited speed and sensitivity. To fill the gap between laboratory-based proof of concept and translational biosensor implementation, we have developed a method to control mass transport of biomolecules under micro- to nanofluidic environments with AC electroosmosis flow. Our new device integrates AC electroosmosis flow-inducing microelectrodes with plasmonic nanoparticle biosensors. Additionally, we have proposed synergetic integration of nanoplasmonic label-free biosensing structures and an ultralow noise MoS₂ photoconductive nanosheet channel. Structurally-engineered metallic nanoparticles used for our device yield a 1000-fold amplification of near-field light localization at their surfaces. This results in a shift of light transmission through the antibody-conjugated nanoparticles, which is extremely sensitive to protein surface binding The nanosheet channel in our device has a few atomic layers of MoS₂. The assembled MoS2 nanosheet shows unique structural and electrical properties that permit high-sensitivity photo signal detection. As a result, our biosensors have shown the ability to detect protein concentrations in the femto-to-pico molar range (a few molecules per cell) with a short (>15 min) sample-to-answer time.

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